PARP Mouse mAb
Poly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD+ ADP-ribosyltransferase 1 or poly[ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. PARP1 has a role in repair of single-stranded DNA (ssDNA) breaks. Knocking down intracellular PARP1 levels with siRNA or inhibiting PARP1 activity with small molecules reduces repair of ssDNA breaks. In the absence of PARP1, when these breaks are encountered during DNA replication, the replication fork stalls, and double-strand DNA (dsDNA) breaks accumulate.
Product Specifications
Background
Product Name Alternative
PARP-1, Poly (ADP ribose) polymerase 1, sPARP1, ADPRT1, ADP ribosyltransferase NAD (+)
UniProt
P09874
Swiss Prot
P09874
Reactivity
Human
Immunogen
Synthetic Peptide
Clonality
Monoclonal
Source
Mouse
Applications
WB, IHC
Concentration
1mg/mL
Dilution
WB 1:1,000-3,000 IHC 1:200-500
Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Molecular Weight
116kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
116kDa
Fragment
IgG1
Subcellular Location
Nucleus
Other Product Names
PARP-1, Poly (ADP ribose) polymerase 1, sPARP1, ADPRT1, ADP ribosyltransferase NAD (+)
Gene ID (Human)
142
Available Sizes
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