Bcl-2 Mouse mAb
BCL2 is an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. BCL2 suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. It regulates cell death by controlling the mitochondrial membrane permeability.
Product Specifications
Background
Product Name Alternative
B-Cell Leukemia/Lymphoma 2 ; B-Cell CLL/Lymphoma 2
UniProt
P10415
Swiss Prot
P10415
Reactivity
Human, Rat, Mouse
Immunogen
Synthetic Peptide
Clonality
Monoclonal
Source
Mouse
Applications
WB, IHC, IF
Concentration
1mg/mL
Dilution
WB 1:1,000-2,000 IHC 1:200 IF 1:100-200
Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Molecular Weight
26kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
26kDa
Fragment
IgG1
Subcellular Location
Mitochondrion outer membrane, Nucleus membrane, Endoplasmic reticulum membrane
Other Product Names
B-Cell Leukemia/Lymphoma 2 ; B-Cell CLL/Lymphoma 2
Gene ID (Human)
596
Available Sizes
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