MS-073

MS-073 (CP162398) is a P-glycoprotein (P-gp) inhibitor. MS-073 reverses multidrug resistance in drug-resistant cells by competitively inhibiting drug binding to P-glycoprotein[1][2].

Product Specifications

CAS Number

[129716-45-6]

Product Name Alternative

CP162398

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

P-glycoprotein

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ms-073.html

Smiles

OC(COC1=C2C=CC=NC2=CC=C1)CN3CCN(CC3)C4C5=CC=CC=C5CCC6=CC=CC=C46

Molecular Formula

C31H33N3O2

Molecular Weight

479.61

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Sato W, et al. Circumvention of multidrug resistance by a newly synthesized quinoline derivative, MS-073[J]. Cancer research, 1991, 51 (9) : 2420-2424.|[2]Smith B J, et al. P-glycoprotein efflux at the blood-brain barrier mediates differences in brain disposition and pharmacodynamics between two structurally related neurokinin-1 receptor antagonists[J]. Journal of Pharmacology and Experimental Therapeutics, 2001, 298 (3) : 1252-1259.