E7820

E7820 (ER68203-00), an orally active aromatic sulfonamide derivative, is a unique angiogenesis inhibitor suppressing an expression of integrin alpha2 subunit on endothelium. E7820 inhibits rat aorta angiogenesis with an IC50 of 0.11 μg/ml. E7820 modulates α-1, α-2, α-3, and α-5 integrin mRNA expression. Antiangiogenic and antitumor activity[1][2].

Product Specifications

CAS Number

[289483-69-8]

Product Name Alternative

ER68203-00

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Integrin; Molecular Glues

Type

Reference compound

Related Pathways

Cytoskeleton; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/E7820.html

Purity

99.26

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=S(C1=CC(C#N)=CC=C1)(NC2=C(NC=C3C#N)C3=C(C)C=C2)=O

Molecular Formula

C17H12N4O2S

Molecular Weight

336.37

Precautions

H315, H319, H320

References & Citations

[1]Funahashi Y, et al. Sulfonamide derivative, E7820, is a unique angiogenesis inhibitor suppressing an expression of integrin alpha2 subunit on endothelium. Cancer Res. 2002;62 (21) :6116-6123.|[2]Ito K, et al. Enhanced anti-angiogenic effect of E7820 in combination with erlotinib in epidermal growth factor receptor-tyrosine kinase inhibitor-resistant non-small-cell lung cancer xenograft models. Cancer Sci. 2014;105 (8) :1023-1031.