α-Hydroxyglutaric acid
α-Hydroxyglutaric acid (2-Hydroxyglutarate) is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[1].
Product Specifications
CAS Number
[2889-31-8]
Product Name Alternative
2-Hydroxyglutarate; 2-Hydroxyglutaric acid; 2-Hydroxypentanedioic acid
UNSPSC
12352211
Hazard Statement
H302, H312, H332
Target
Endogenous Metabolite; Histone Demethylase
Type
Reference compound
Related Pathways
Epigenetics; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/α-hydroxyglutaric-acid.html
Concentration
67.52 mM * 0.5mL in Ethanol
Purity
99.0
Solubility
10 mM in DMSO
Smiles
O=C(O)C(O)CCC(O)=O
Molecular Formula
C5H8O5
Molecular Weight
148.11
Precautions
H302, H312, H332
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite; Microbial Metabolite
Available Sizes
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