A 1120

A 1120 is a high-affinity nonretinoid retinol-binding protein 4 (RBP4) antagonist with a Ki value of 8.3 nM. A 1120 disrupts the interaction between RBP4 and its binding partner transthyretin[1][2].

Product Specifications

CAS Number

[1152782-19-8]

UNSPSC

12352005

Hazard Statement

H302, H317, H319, H400

Target

Transthyretin (TTR)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/a-1120.html

Purity

99.73

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC(F)(C1=C(C2CCN(C(NC3=C(C=CC=C3)C(O)=O)=O)CC2)C=CC=C1)F

Molecular Formula

C20H19F3N2O3

Molecular Weight

392.37

Precautions

H302, H317, H319, H400

References & Citations

[1]Motani A, et al. Identification and characterization of a non-retinoid ligand for retinol-binding protein 4 which lowers serum retinol-binding protein 4 levels in vivo. J Biol Chem. 2009 Mar 20;284 (12) :7673-80.|[2]Dobri N, et al. A1120, a nonretinoid RBP4 antagonist, inhibits formation of cytotoxic bisretinoids in the animal model of enhanced retinal lipofuscinogenesis. Invest Ophthalmol Vis Sci. 2013 Jan 7;54 (1) :85-95.