DPI-4452

DPI-4452 is a CAIX-targeting cyclic peptide with a DOTA cage, and can be chelated with radionuclide for CAIX-expressing tumor PET-CT imaging and study. DPI-4452 specifically and selectively binds CAIX without interaction with an in vitro off-target receptor panel of 55 targets (IC50 for recombinant hCAIX: 130 nM) . Radiolabeled DPI-4452 inhibits tumor growth in HT-29 and SK-RC-52 xenograft mouse models[1]. DPI-4452 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs) .

Product Specifications

CAS Number

[2941391-49-5]

UNSPSC

12352209

Target

Carbonic Anhydrase; Radionuclide-Drug Conjugates (RDCs)

Type

Peptides

Related Pathways

Antibody-drug Conjugate/ADC Related; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dpi-4452.html

Purity

98.27

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C[C@@H](O)[C@H](NC([C@@H](N1)CC(C)C)=O)C(N[C@@H](CC2=CNC3=C2C=CC=C3)C(N[C@H](C(N[C@@H](CSCC4=CC(CSC[C@H](NC([C@@H](NC(CN5CCN(C(CN(CCN6CC(O)=O)CCN(CCN(CC(O)=O)CC6)CC(O)=O)=O)CC5)=O)CCC(N)=O)=O)C(N[C@@H](CCC(O)=O)C(N(CCC7)[C@H]7C(N[C@@H](CC(O)=O)C(N[C@@H](CC8=CC=CC(NC(CCCS(=O)(N)=O)=O)=C8)C1=O)=O)=O)=O)=O)=CC=C4)C(N)=O)=O)CO)=O)=O

Molecular Formula

C92H132N22O29S3

Molecular Weight

2106.36

References & Citations

[1]1. Massière, et al. Preclinical Characterization of DPI-4452: A68Ga/177Lu Theranostic Ligand for Carbonic Anhydrase IX. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2024, 65 (5), 761–767.