GR79236

GR79236 is a highly potent, selective and orally active adenosine A1 receptor agonist with a Kis of 3.1 nM and 1300 nM for A1 and A2 receptors, respectively. GR79236 has anti-nociceptive and anti-inflammatory actions[1][2].

Product Specifications

CAS Number

[124555-18-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Adenosine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/GR79236.html

Concentration

10mM

Purity

99.89

Solubility

DMSO : ≥ 100 mg/mL|H2O : 100 mg/mL (ultrasonic)

Smiles

OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C2N=CN=C3N[C@@H]4[C@@H](O)CCC4)O1)O)O

Molecular Formula

C15H21N5O5

Molecular Weight

351.36

Precautions

H302, H315, H319, H335

References & Citations

[1]Sneyd JR, et al. Multicentre evaluation of the adenosine agonist GR79236X in patients with dental pain after third molar extraction. Br J Anaesth. 2007 May;98 (5) :672-676.|[2]L J Knutsen, et al. N-substituted adenosines as novel neuroprotective A (1) agonists with diminished hypotensive effects. J Med Chem. 1999 Sep 9;42 (18) :3463-77.|[3]P Strong, et al. Suppression of non-esterified fatty acids and triacylglycerol in experimental animals by the adenosine analogue GR79236. Clin Sci (Lond) . 1993 Jun;84 (6) :663-9.