Iberin

Iberin (NSC 321801), a sulfoxide analogue of sulforaphane, is a naturally occurring member of isothiocyanate family. Iberin inhibits cell survival with an IC50 of 2.3 μM in HL60 cell. Iberin induces apoptosis.

Product Specifications

CAS Number

[505-44-2]

Product Name Alternative

NSC 321801

UNSPSC

12352211

Hazard Statement

H301+H311+H331, H315, H319, H335, H410

Target

Apoptosis; Bacterial; Endogenous Metabolite

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Iberin.html

Concentration

61.25 mM * 1 mL in Ethanol

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=S(CCCN=C=S)C

Molecular Formula

C5H9NOS2

Molecular Weight

163.26

Precautions

H301+H311+H331, H315, H319, H335, H410

References & Citations

[1]Jakubikova J, et al. Isothiocyanates induce cell cycle arrest, apoptosis and mitochondrial potential depolarization in HL-60 and multidrug-resistant cell lines. Anticancer Res. 2005 Sep-Oct;25 (5) :3375-86.|[2]Jadhav U, et al. Iberin induces cell cycle arrest and apoptosis in human neuroblastoma cells.|[3]Jadhav U, et al. Dietary isothiocyanate iberin inhibits growth and induces apoptosis in human glioblastoma cells. J Pharmacol Sci. 2007 Feb;103 (2) :247-51.|[4]Jakobsen TH, et al. Food as a source for quorum sensing inhibitors: iberin from horseradish revealed as a quorumsensing inhibitor of Pseudomonas aeruginosa. Appl Environ Microbiol. 2012 Apr;78 (7) :2410-21.|[5]Munday R, et al. Induction of phase II detoxification enzymes in rats by plant-derived isothiocyanates: comparison of allyl isothiocyanate with sulforaphane and related compounds. J Agric Food Chem. 2004 Apr 7;52 (7) :1867-71.