CHPG (sodium salt)
CHPG sodium salt is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells[1]. CHPG sodium salt protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways.[2].
Product Specifications
CAS Number
[1303993-73-8]
UNSPSC
12352005
Target
Akt; ERK; mGluR; NF-κB
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; Neuronal Signaling; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/chpg-sodium-salt.html
Concentration
10mM
Purity
99.25
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 6.67 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C(O[Na])C(N)C1=CC(O)=CC=C1Cl
Molecular Formula
C8H7ClNNaO3
Molecular Weight
223.59
References & Citations
2
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERK; mGluR5; NF-κB
Citation 01
Available Sizes
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