PF-DcpSi
Product Specifications
UNSPSC Description
PF-DcpSi is a mRNA decapping scavenger enzyme (DcpS) inhibitor (IC50: 0.11 nM). PF-DcpSi (30 mg/kg,i.p.) ameliorates the disease phenotype in a mice model of spinal muscular atrophy (SMA)[1].
Target Antigen
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pf-dcpsi.html
Smiles
N#CC1=CC(F)=CC(OCC2=CC=CC3=NC(N)=NC(N)=C23)=C1
Molecular Weight
309.30
References & Citations
[1]Gopalsamy A, et al. Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA). J Med Chem. 2017 Apr 13;60(7):3094-3108.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-122604/PF-DcpSi-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-122604/
Clinical Information
Phase 1
CAS Number
2092917-19-4
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6377825-01 0.1 mL
EZR (Ezrin, Cytovillin, Villin-2, p81, VIL2, CVIL, CVL, DKFZp762H157, FLJ26216, MGC1584) (FITC)
Ask
View Details MBS6377825-02 5x 0.1 mL
EZR (Ezrin, Cytovillin, Villin-2, p81, VIL2, CVIL, CVL, DKFZp762H157, FLJ26216, MGC1584) (FITC)
Ask
View Details 