NX-1607
Product Specifications
UNSPSC Description
NX-1607 (Compound 23) is an inhibitor of Cbl-b, an E3 enzyme in the ubiquitin-proteasome pathway, with an IC50 value of less than 1 nM. NX-1607 can be used in cancer research[1].
Target Antigen
E1/E2/E3 Enzyme
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nx-1607.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN1C([C@@]2(C3=CC(N4CC5=C(C(F)(F)F)C=C(CN6C[C@H](CCC6)C)C=C5C4=O)=CC=C3)C[C@H](C2)C)=NN=C1
Molecular Weight
537.62
References & Citations
[1]Arthur T. Sands, et al. Substituted benzyl-triazole compounds for cbl-b inhibition, and further uses thereof. WO2020264398A1.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-141432/NX-1607-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-141432/Cbl-b-IN-3-SDS-MedChemExpress.pdf
Clinical Information
Phase 1
CAS Number
2573775-59-2
Available Sizes
Curated Selection
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