20 (S) -Hydroxycholesterol
20 (S) -Hydroxycholesterol (20α-Hydroxycholesterol) is an allosteric activator that selectively targets the Smoothened (Smo) of the Hedgehog pathway with an EC50 of ~30 μM (Hedgehog) . 20 (S) -Hydroxycholesterol binds to the extracellular cysteine-rich domain (CRD) of Smo in a stereoselective manner, activating downstream Gli transcription factors (without inducing transcription of receptor genes in the Wnt pathway) . 20 (S) -Hydroxycholesterol enhances osteogenic differentiation of bone marrow stromal cells and synergistically activates the Raf/MEK/ERK pathway with Simvastatin (HY-17502) to promote bone regeneration. 20 (S) -Hydroxycholesterol can be used to study the mechanisms of developmental biology, oncology, bone, and angiogenesis[1][2][3].
Product Specifications
CAS Number
[516-72-3]
Product Name Alternative
20α-Hydroxycholesterol
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite; Smo
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer; Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/20-s-hydroxycholesterol.html
Purity
99.29
Solubility
DMSO : 12.5 mg/mL (ultrasonic)
Smiles
C[C@@]1([C@@]2([H])[C@@](C)(O)CCCC(C)C)[C@](CC2)([H])[C@@](CC=C3[C@@]4(CC[C@H](O)C3)C)([H])[C@]4([H])CC1
Molecular Formula
C27H46O2
Molecular Weight
402.65
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
IFNA10, CT (IFNA10, Interferon alpha-10, Interferon alpha-6L, Interferon alpha-C) (APC) discontinued
