PBIT

PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1 (JARID1) enzymes. PBIT inhibits JARID1B (KDM5B or PLU1) histone demethylase with an IC50 of about 3 μM . PBIT also inhibits JARID1A and JARID1C with IC50s of 6 μM and 4.9 μM, respectively[1].

Product Specifications

CAS Number

[2514-30-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Histone Demethylase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pbit.html

Purity

99.46

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1N(C2=CC=C(C)C=C2)SC3=C1C=CC=C3

Molecular Formula

C14H11NOS

Molecular Weight

241.31

Precautions

H302, H315, H319, H335

References & Citations

[1]Sayegh J, et al. Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen. J Biol Chem. 2013 Mar 29;288 (13) :9408-17.