SJ26
SJ26 is a Wnt1 inhibitor with anticancer activity. SJ26 inhibits the expression of Wnt1 and Wnt1-mediated downstream signaling pathways in a G-quadruplex structure-dependent manner to suppress the migration activity of cancer cells[1].
Product Specifications
CAS Number
[1801288-67-4]
UNSPSC
12352005
Target
G-quadruplex; Wnt
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sj26.html
Purity
98.65
Solubility
DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C2=CC(Cl)=CC=C2C3=C1C4=C(C=CC=C4)N=C3N5CCC(CCCC6CCNCC6)CC5
Molecular Formula
C29H32ClN3O
Molecular Weight
474.04
References & Citations
[1]Liencheng Chang, et al. "Identification of a new class of WNT1 inhibitor: Cancer cells migration, G-quadruplex stabilization and target validation." Oncotarget 7.42 (2016) : 67986.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Wnt1
Available Sizes
Curated Selection
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