SJ26

SJ26 is a Wnt1 inhibitor with anticancer activity. SJ26 inhibits the expression of Wnt1 and Wnt1-mediated downstream signaling pathways in a G-quadruplex structure-dependent manner to suppress the migration activity of cancer cells[1].

Product Specifications

CAS Number

[1801288-67-4]

UNSPSC

12352005

Target

G-quadruplex; Wnt

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Stem Cell/Wnt

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sj26.html

Purity

98.65

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C2=CC(Cl)=CC=C2C3=C1C4=C(C=CC=C4)N=C3N5CCC(CCCC6CCNCC6)CC5

Molecular Formula

C29H32ClN3O

Molecular Weight

474.04

References & Citations

[1]Liencheng Chang, et al. "Identification of a new class of WNT1 inhibitor: Cancer cells migration, G-quadruplex stabilization and target validation." Oncotarget 7.42 (2016) : 67986.