LDN-27219
Product Specifications
UNSPSC Description
LDN-27219 is a reversible, slow-binding inhibitor of TGase. LDN-27219 inhibits human TGase with an IC50 value of 0.6 μM. LDN-27219 effectively decreases blood pressure and induces vasodilation, it can be used for the research of cardiovascular disease[1][2].
Target Antigen
Others
Type
Reference compound
Related Pathways
Others
Field of Research
Others; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/LDN-27219.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N(C2=CC=CC=C2)C(SCC(NN)=O)=NC3=C1C(C4=CC=CC=C4)=CS3
Molecular Weight
408.50
References & Citations
[1]Case A, et al. Kinetic analysis of the interaction of tissue transglutaminase with a nonpeptidic slow-binding inhibitor. Biochemistry. 2007 Jan 30;46(4):1106-15.|[2]Pinilla E, et al. Transglutaminase 2 Inhibitor LDN 27219 Age-Dependently Lowers Blood Pressure and Improves Endothelium-Dependent Vasodilation in Resistance Arteries. Hypertension. 2021 Jan;77(1):216-227.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-16693/LDN-27219-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-16693/LDN-27219-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
312946-37-5
Available Sizes
Curated Selection
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