Dapsone (Standard)

Dapsone (Standard) is the analytical standard of Dapsone. This product is intended for research and analytical applications. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al[2][3].

Product Specifications

CAS Number

[80-08-0]

Product Name Alternative

4,4′-Diaminodiphenyl sulfone (Standard) ; DDS (Standard)

UNSPSC

12352005

Hazard Statement

H302, H360, H371, H373, H411

Target

Antibiotic; Bacterial; Parasite; Reactive Oxygen Species (ROS) ; Reference Standards

Type

Reference Standards

Related Pathways

Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/dapsone-standard.html

Purity

99.77

Smiles

O=S(C1=CC=C(N)C=C1)(C2=CC=C(N)C=C2)=O

Molecular Formula

C12H12N2O2S

Molecular Weight

248.30

Precautions

H302, H360, H371, H373, H411

References & Citations

[1]Y I Zhu, et al. Dapsone and sulfones in dermatology: overview and update. J Am Acad Dermatol|[2]Dapsone, Drug.com|[3]D Voeller, et al. Interaction of Pneumocystis carinii dihydropteroate synthase with sulfonamides and diaminodiphenyl sulfone (dapsone) .J Infect Dis. 1994 Feb;169 (2) :456-9.|[4]Esther Moreno, et al. Evaluation of Skin Permeation and Retention of Topical Dapsone in Murine Cutaneous Leishmaniasis Lesions.Pharmaceutics. 2019 Nov 13;11 (11) :607.