AZD3458

AZD3458 is a potent and remarkably selective PI3Kγ inhibitor with pIC50s of 9.1, 5.1, PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively[1].

Product Specifications

CAS Number

[2132961-46-5]

UNSPSC

12352005

Target

PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/PI3K_gamma__inhibitor_3.html

Purity

99.71

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C1N([C@@H](C)C2CC2)CC3=CC(C4=C(C)N=C(NC(C)=O)S4)=CC(S(=O)(C)=O)=C31

Molecular Formula

C20H23N3O4S2

Molecular Weight

433.54

References & Citations

[1]Pemberton N, et al. Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3-Kinase (PI3K) -γ Inhibitors. J Med Chem. 2018 Jun 28;61 (12) :5435-5441.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PI3KC2α; PI3KC2β; PI3KC2γ; PI3KC3; PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ

Available Sizes

Curated Selection

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