AM1172

AM1172 is metabolically stable anandamide uptake inhibitor. AM1172 inhibits [3H] anandamide transport in rat cortical neurons and human CCF-STTG1 astrocytoma cells with IC50 values of 2.1 μM and 2.5 μM, respectively. AM1172 can significantly inhibit AEA hydrolysis and concurrently decrease AEA uptake. AM1172 can be used for the study of endocannabinoid system regulation[1][2][3].

Product Specifications

CAS Number

[251908-92-6]

UNSPSC

12352005

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/am1172.html

Concentration

24.41 mM * 1 mL in Ethanol

Purity

99.0

Solubility

10 mM in DMSO

Smiles

O=C(NCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)C1=CC=C(O)C=C1

Molecular Formula

C27H39NO2

Molecular Weight

409.60

References & Citations

[1]Fegley D, et al. Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172. Proc Natl Acad Sci U S A. 2004 Jun 8;101 (23) :8756-61. |[2]Kaczocha M, et al. Anandamide uptake is consistent with rate-limited diffusion and is regulated by the degree of its hydrolysis by fatty acid amide hydrolase. J Biol Chem. 2006 Apr 7;281 (14) :9066-75.|[3]Fegley D, et al. Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172. Proc Natl Acad Sci U S A. 2004 Jun 8;101 (23) :8756-61.