Undecane

Undecane is a potent cAMP agonist with anti-allergic and anti-inflammatory activities. Undecane inhibits degranulation and the secretion of histamine and TNF-α. Undecane reverses the increased levels of p38 phosphorylation, NF-κB transcriptional activity and target cytokine/chemokine genes, including thymus and activation-regulated chemokine (TARC), macrophage-derived chemokine (MDC) and interleukin-8 (IL-8) . Undecane can be used for the study of skin inflammatory disorders, such as atopic dermatitis[1].

Product Specifications

CAS Number

[1120-21-4]

UNSPSC

12352211

Hazard Statement

H226, H304

Target

Histamine Receptor; Interleukin Related; NF-κB; p38 MAPK; PKA; TNF Receptor

Type

Natural Products

Related Pathways

Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway; Neuronal Signaling; NF-κB; Stem Cell/Wnt; TGF-beta/Smad

Applications

COVID-19-immunoregulation

Field of Research

Endocrinology; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/undecane.html

Purity

99.66

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCCCCCCCCCC

Molecular Formula

C11H24

Molecular Weight

156.31

Precautions

H226, H304

References & Citations

[1]Choi D, Kang W, Park T. Anti-Allergic and Anti-Inflammatory Effects of Undecane on Mast Cells and Keratinocytes. Molecules. 2020;25 (7) :1554. Published 2020 Mar 28.