E235
Product Specifications
UNSPSC Description
E235 is an expression regulator of activates transcription factor 4 (ATF4). E235 reduces cell viability by activating integrated stress response (ISR) and DNA damage response signals. E235 has anti-proliferative activity and can be used for tumor research[1].
Target Antigen
Eukaryotic Initiation Factor (eIF)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/e235.html
Solubility
DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C(C1=CC=C2N3C(SC2=C1)=NC(C4=CC=C(F)C=C4)=C3)NC5CCN(CC6=CC=CC=C6)CC5
Molecular Weight
484.59
References & Citations
[1]Sayers CM, et al. Identification and characterization of a potent activator of p53-independent cellular senescence via a small-molecule screen for modifiers of the integrated stress response. Mol Pharmacol. 2013 Mar;83(3):594-604.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-153339/E235-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-153339/E235-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
891894-69-2
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS2041837-01 0.1 mL
APC-Linked Polyclonal Antibody to Tissue Factor Pathway Inhibitor (TFPI)
Ask
View Details 
MBS2041837-02 0.2 mL
APC-Linked Polyclonal Antibody to Tissue Factor Pathway Inhibitor (TFPI)
Ask
View Details MBS2041837-03 0.5 mL
APC-Linked Polyclonal Antibody to Tissue Factor Pathway Inhibitor (TFPI)
Ask
View Details MBS2041837-04 1 mL
APC-Linked Polyclonal Antibody to Tissue Factor Pathway Inhibitor (TFPI)
Ask
View Details MBS2041837-05 5 mL
APC-Linked Polyclonal Antibody to Tissue Factor Pathway Inhibitor (TFPI)
Ask
View Details