SU4312

SU4312 is the racemate of (Z) -SU4312 and (E) -SU4312. (Z) -SU4312 inhibits PDGFR and FLK-1 with IC50s of 19.4 and 0.8 μM, respectively. (E) -SU4312 inhibits PDGFR, FLK-1, EGFR, HER-2, and IGF-1R with IC50s of 24.2, 5.2, 18.5, 16.9 and 10.0 μM, respectively[1].

Product Specifications

CAS Number

[5812-07-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PDGFR; VEGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/su4312.html

Purity

99.74

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1NC2=C(C=CC=C2)/C1=C/C3=CC=C(N(C)C)C=C3

Molecular Formula

C17H16N2O

Molecular Weight

264.32

Precautions

H302, H315, H319, H335

References & Citations

[1]L Sun, et al. Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases. J Med Chem. 1998 Jul 2;41 (14) :2588-603.