ST1936

ST1936 is a selective, nanomolar affinity 5-HT6 receptor agonist with Ki values of 13 nM, 168 nM and 245 nM for human 5-HT6, 5-HT7 and 5-HT2B receptors, respectively. ST1936 also shows moderate affinity (Ki of 300 nM) for human and rat α2 adrenergic receptor[1].

Product Specifications

CAS Number

[1210-81-7]

UNSPSC

12352005

Hazard Statement

H302

Target

5-HT Receptor; Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/st1936.html

Purity

99.70

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(N1)=C(CCN(C)C)C2=C1C=CC(Cl)=C2

Molecular Formula

C13H17ClN2

Molecular Weight

236.74

Precautions

P264-P270-P330-P501

References & Citations

[1]Borsini F, et al. Effects of ST1936, a selective serotonin-6 agonist, on electrical activity of putative mesencephalic dopaminergic neurons in the rat brain. J Psychopharmacol. 2015 Jul;29 (7) :802-11.|[2]Riccioni T, et al. ST1936 stimulates cAMP, Ca2+, ERK1/2 and Fyn kinase through a full activation of cloned human 5-HT6 receptors. Eur J Pharmacol. 2011;661 (1-3) :8-14. |[3]Tassone A, et al. Activation of 5-HT6 receptors inhibits corticostriatal glutamatergic transmission. Neuropharmacology. 2011;61 (4) :632-637. |[4]Valentini V, et al. A microdialysis study of ST1936, a novel 5-HT6 receptor agonist. Neuropharmacology. 2011;60 (4) :602-608.