PDDC
PDDC is a compound used to inhibit Alzheimer's disease. It is a nSMase2 inhibitor that can inhibit tau-induced nSMase2 activity and ceramide elevation, and slow the spread of tau in mouse models.
Product Specifications
CAS Number
[2232878-43-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/pddc.html
Concentration
10mM
Purity
99.97
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=C(C2=CC(OC)=C(C=C2)OC)N(N=C(C=C3N4C[C@@H](CC4)NC(OC5=CC=CC=C5)=O)C)C3=N1
Molecular Formula
C27H29N5O4
Molecular Weight
487.55
Precautions
H302, H315, H319
References & Citations
[1]Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in an Alzheimer's disease mouse model
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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