Cercosporamide
Product Specifications
UNSPSC Description
Cercosporamide is a highly potent, ATP-competitive PKC kinase inhibitor targeting to PKC1, with an IC50 of Ki of Mnk inhibitor.
Target Antigen
Fungal; MNK; PKC
Type
Natural Products
Related Pathways
Anti-infection;Epigenetics;MAPK/ERK Pathway;TGF-beta/Smad
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/Cercosporamide.html
Solubility
DMSO : 1 mg/mL (ultrasonic;warming)
Smiles
O=C(C1=C(C([C@@]23C)=C(O)C=C1O)OC2=CC(O)=C(C(C)=O)C3=O)N
Molecular Weight
331.28
References & Citations
[1]Sussman A, et al. Discovery of Cercosporamide, a known antifungal natural product, as a selective Pkc1 kinase inhibitor through high-throughput screening. Eukaryot Cell. 2004 Aug;3(4):932-43.|[2]Altman JK, et al. Inhibition of Mnk kinase activity by Cercosporamide and suppressive effects on acute myeloid leukemia precursors. Blood. 2013 May 2;121(18):3675-81.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-16982/Cercosporamide-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-16982/Cercosporamide-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
131436-22-1
Available Sizes
Curated Selection
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