Tandospirone

Tandospirone (SM-3997) is a potent and selective 5-HT1A receptor partial agonist, with a Ki of 27 nM. Tandospirone has anxiolytic and antidepressant activities. Tandospirone can be used for the research of the central nervous system disorders and the underlying mechanisms[1][2][3].

Product Specifications

CAS Number

[87760-53-0]

Product Name Alternative

SM-3997

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Tandospirone.html

Concentration

10mM

Purity

99.41

Solubility

DMSO : 16.67 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

O=C1[C@]2([H])[C@]([C@H]3CC[C@@H]2C3)([H])C(N1CCCCN(CC4)CCN4C5=NC=CC=N5)=O

Molecular Formula

C21H29N5O2

Molecular Weight

383.49

Precautions

H315, H319, H335

References & Citations

[1]Hamik A, et al. Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites. Biol Psychiatry. 1990 Jul 15;28 (2) :99-109.|[2]Xuefei Huang, et al. Role of tandospirone, a 5-HT1A receptor partial agonist, in the treatment of central nervous system disorders and the underlying mechanisms. Oncotarget. 2017 Nov 24; 8 (60) : 102705–102720.|[3]Kyoko Nishitsuji, et al. The pharmacokinetics and pharmacodynamics of tandospirone in rats exposed to conditioned fear stress. Eur Neuropsychopharmacol. 2006 Jul;16 (5) :376-82.