Hamamelitannin

Hamamelitannin, a polyphenol extracted from the bark of Hamamelis virginiana, is a quorum-sensing (QS) inhibitor. Hamamelitannin increases antibiotic susceptibility of staphylococcus aureus biofilms by affecting peptidoglycan biosynthesis and eDNA release[1][2].

Product Specifications

CAS Number

[469-32-9]

UNSPSC

12352005

Target

Bacterial

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/hamamelitannin.html

Purity

99.43

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C[C@]([C@@H]([C@@H](COC(C1=CC(O)=C(O)C(O)=C1)=O)O)O)(COC(C2=CC(O)=C(O)C(O)=C2)=O)O

Molecular Formula

C20H20O14

Molecular Weight

484.36

References & Citations

[1]Kiran MD, et al. Discovery of a quorum-sensing inhibitor of drug-resistant staphylococcal infections by structure-based virtual screening. Mol Pharmacol. 2008 May;73 (5) :1578-86.|[2]Cobrado L, et al. In vivo antibiofilm effect of cerium, chitosan and hamamelitannin against usual agents of catheter-related bloodstream infections. J Antimicrob Chemother. 2013 Jan;68 (1) :126-30.|[3]Sánchez-Tena S, et al. Hamamelitannin displays specific cytotoxic activity against colon cancer cells. J Nat Prod. 2012 Jan 27;75 (1) :26-33.