RS102895
Product Specifications
UNSPSC Description
RS102895 is a potent CCR2 antagonist, with an IC50 of 360 nM, and shows no effect on CCR1.
Target Antigen
CCR
Type
Reference compound
Related Pathways
GPCR/G Protein;Immunology/Inflammation
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/RS102895.html
Purity
99.97
Solubility
DMSO : 250 mg/mL (ultrasonic)|Ethanol : 50 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C1NC2=CC=CC=C2C3(CCN(CCC4=CC=C(C(F)(F)F)C=C4)CC3)O1
Molecular Weight
390.40
References & Citations
[1]Mirzadegan T, et al. Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle. J Biol Chem. 2000 Aug 18;275(33):25562-71.|[2]Park J, et al. MCP-1/CCR2 system is involved in high glucose-induced fibronectin and type IV collagen expression in cultured mesangial cells. Am J Physiol Renal Physiol. 2008 Sep;295(3):F749-57.|[3]Ren F, et al. Analgesic Effect of Intrathecal Administration of Chemokine Receptor CCR2 Antagonist is Related to Change in Spinal NR2B, nNOS, and SIGIRR Expression in Rat with Bone Cancer Pain. Cell Biochem Biophys. 2015 Jun;72(2):611-6.Eur J Pharmacol. 2021, 174165.|Exp Cell Res. 2020 Nov 1;396(1):112289.|Hum Reprod. 2019 Apr 1;34(4):646-658.|J Eur Acad Dermatol Venereol. 2020 Apr;34(4):862-872.|J Interferon Cytokine Res. 2019 Apr;39(4):224-232. |J Interferon Cytokine Res. 2020 May;40(5):245-253.|Life Sci. 2020 Nov 15;261:118360.|Stem Cell Res Ther. 2021 Jul 2;12(1):378.|Cell Death Dis. 2022 Feb 17;13(2):158.|Int Immunopharmacol. 2023 Feb.|J Adv Res. 2020 Jul 22;28:231-243.|J Adv Res. 2024 Apr 14:S2090-1232(24)00155-3.|J Neuroinflammation. 2023 Nov 17;20(1):270.|Liver Int. 2022 Sep 27.|Mol Med Rep. 2017 Sep;16(3):3387-3394. |Nat Immunol. 2024 Sep 02.|Sci Adv. 2023 Aug 2;9(31):eadg6856.|Theranostics. 2020 Apr 27;10(13):5687-5703
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-18611A/RS102895-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-18611A/RS102895-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
300815-41-2
Available Sizes
Curated Selection
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