BIO-2007817
Product Specifications
UNSPSC Description
BIO-2007817 is a Parkin positive allosteric modulators (PAMs). BIO-2007817 enhances the activity of wildtype Parkin. BIO-2007817 stimulates Parkin (an E3 ligase)autoubiquitination and induces the appearance of monoubiquitinated forms of Miro1 (EC50: 0.17 μM)[1].
Target Antigen
E1/E2/E3 Enzyme; PINK1/Parkin
Type
Reference compound
Related Pathways
Autophagy;Metabolic Enzyme/Protease;Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bio-2007817.html
Smiles
CO[C@@H](C1=CN(N=C1)C)C(N2CC3=C(C=NN3C[C@H]2C(C)C)C4=CC=C(C=C4)C(N5CCCC6=C5C=CC=C6)=O)=O
Molecular Weight
552.67
References & Citations
[1]Shlevkov E, et al. Discovery of small-molecule positive allosteric modulators of Parkin E3 ligase. iScience. 2021 Dec 18;25(1):103650.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-169329/BIO-2007817-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-169329/
Clinical Information
No Development Reported
Curated Selection
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