PF-07258669

PF-07258669 is an orally active melanocortin-4 receptor (MC4R) antagonist that antagonizes MC4R with an IC50 of 13 nM (Ki=0.46 nM) . PF-07258669 can be used for the research of cachexia, anorexia, or anorexia nervosa[1].

Product Specifications

CAS Number

[2755890-53-8]

UNSPSC

12352005

Target

Melanocortin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pf-07258669.html

Purity

98.44

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(N=C(N1)C(CC[C@]21CCN(C([C@H](C)C3=C(C=NC(OC)=C3)F)=O)C2)=C4)=C4C5=NC=CC=N5

Molecular Formula

C25H27FN6O2

Molecular Weight

462.52

References & Citations

[1]Christopher Ryan BUTLER, et al. Spiro compounds as melanocortin 4 receptor antagonists and uses thereof. Patent. WO2021250541A1.|[2]Garnsey MR, et al., Discovery of the Potent and Selective MC4R Antagonist PF-07258669 for the Potential Treatment of Appetite Loss. J Med Chem. 2023 Mar 9;66 (5) :3195-3211.