(-) -Hinesol

(-) -Hinesol (Hinesol) is a potent anticancer agent. (-) -Hinesol induces apoptosis and cell cycle arrest at G0/G1 phase. (-) -Hinesol downregulates MEK/ERK pathway and NF-κB pathway and mediates theexpression of cyclin D1, Bax and Bcl-2. (-) -Hinesol has the potential for the research of non–small cell lung cancer[1].

Product Specifications

CAS Number

[23811-08-7]

Product Name Alternative

Hinesol

UNSPSC

12352211

Target

Apoptosis

Type

Natural Products

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/minus-hinesol.html

Purity

98.7

Solubility

10 mM in DMSO

Smiles

C[C@@H]1[C@]2(C[C@H](C(O)(C)C)CC2)C(C)=CCC1

Molecular Formula

C15H26O

Molecular Weight

222.37

References & Citations

[1]Guo W, et al. The antitumor effect of hinesol, extract from Atractylodes lancea (Thunb.) DC. by proliferation, inhibition, and apoptosis induction via MEK/ERK and NF-κB pathway in non-small cell lung cancer cell lines A549 and NCI-H1299. J Cell Biochem. 2019 Nov;120 (11) :18600-18607.