Fludrocortisone

Fludrocortisone inhibits natriuresis. Fludrocortisone is a synthetic mineralocorticoid with anti-inflammatory activity. Fludrocortisone can be studied in research for small cell lung cancer with profound hyponatremia and acute neurological symptoms as well as aneurysmal subarachnoid hemorrhage[1][2].

Product Specifications

CAS Number

[127-31-1]

Product Name Alternative

9α-Fludrocortisone; 9α-Fluorcortisol

UNSPSC

12352211

Hazard Statement

H302, H312, H332, H361

Target

Mineralocorticoid Receptor; Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/Fludrocortisone.html

Purity

98.99

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@](C(CO)=O)(O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3(F)[C@@H](O)C2)=O

Molecular Formula

C21H29FO5

Molecular Weight

380.45

Precautions

H302, H312, H332, H361

References & Citations

[1]Jaal J, et al. Small Cell Lung Cancer Patient with Profound Hyponatremia and Acute Neurological Symptoms: An Effective Treatment with Fludrocortisone. Case Rep Oncol Med. 2015;2015:286029.|[2]Mori T, et al. Improved efficiency of hypervolemic therapy with inhibition of natriuresis by fludrocortisone in patients with aneurysmal subarachnoid hemorrhage. Journal of Neurosurgery [1999, 91 (6) :947-952]