STIMA-1
STIMA-1 can stimulate mutant p53 DNA binding in vitro and induce expression of p53 target proteins and trigger apoptosis in mutant p53-expressing human tumor cells[1].
Product Specifications
CAS Number
[91634-12-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/stima-1.html
Purity
98.40
Solubility
DMSO : 250 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1NC(C=C)=NC2=C1C=CC=C2
Molecular Formula
C10H8N2O
Molecular Weight
172.18
Precautions
H302, H315, H319, H335
References & Citations
[1]Nicole Zache, et al. Mutant p53 targeting by the low molecular weight compound STIMA-1. Mol Oncol. 2017 May;11 (5) :595.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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