4-Hydroxyderricin

4-Hydroxyderricin, the major active ingredients of Angelica keiskei Koidzumi, is an orally active, potent selective MAO-B (Monoamine oxidase inhibitors) inhibitor with an IC50 of 3.43 μM. 4-Hydroxyderricin also mildly inhibits dopamine β (DBH) -hydroxylase activity. 4-Hydroxyderricin has antidepressant activity, anti-allergic, anti-diabetic, anti-oxidant, and antitumor effects. 4-Hydroxyderricin promotes apoptosis and cell cycle arrest through regulating PI3K/AKT/mTOR pathway in hepatocellular cells. 4-Hydroxyderricin inhibits osteoclast formation and accelerates osteoblast differentiation[1]. 4-Hydroxyderricin is promising for research of inflammatory diseases[1][2][3][4][5].

Product Specifications

CAS Number

[55912-03-3]

UNSPSC

12352005

Target

Apoptosis; Dopamine β-hydroxylase; Monoamine Oxidase

Type

Natural Products

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/4-hydroxyderricin.html

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C(OC)C(C/C=C(C)\C)=C1O)/C=C/C2=CC=C(O)C=C2

Molecular Formula

C21H22O4

Molecular Weight

338.40

References & Citations

[1]Kim JH, et al. Xanthoangelol and 4-Hydroxyderricin Are the Major Active Principles of the Inhibitory Activities against Monoamine Oxidases on Angelica keiskei K. Biomol Ther (Seoul) . 2013 May 30;21 (3) :234-40.|[2]Hagiwara H, et al. 4-Hydroxyderricin inhibits osteoclast formation and accelerates osteoblast differentiation. Cytotechnology. 2019 Feb;71 (1) :15-22.|[3]Kimura Y, et al. Antitumor and antimetastatic activities of 4-hydroxyderricin isolated from Angelica keiskei roots. Planta Med. 2004 Mar;70 (3) :211-9.|[4]Yasuda M, et al. Inhibitory effects of 4-hydroxyderricin and xanthoangelol on lipopolysaccharide-induced inflammatory responses in RAW264 macrophages. J Agric Food Chem. 2014 Jan 15;62 (2) :462-7.|[5]Gao X, et al. 4-Hydroxyderricin Promotes Apoptosis and Cell Cycle Arrest through Regulating PI3K/AKT/mTOR Pathway in Hepatocellular Cells. Foods. 2021 Aug 29;10 (9) :2036.