Oglufanide

Oglufanide (H-Glu-Trp-OH) is a dipeptide immunomodulator isolated from calf thymus. Oglufanide inhibits vascular endothelial growth factor (VEGF) . Oglufanide can stimulate the immune response to hepatitic C virus (HCV) and intracellular bacterial infections. Oglufanide shows antitumor and anti-angiogenesis activities[1][2][3].

Product Specifications

CAS Number

[38101-59-6]

Product Name Alternative

H-Glu-Trp-OH; L-Glutamyl-L-tryptophan

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; HCV; VEGFR

Type

Natural Products

Related Pathways

Anti-infection; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Oglufanide.html

Purity

98.97

Solubility

DMSO : 15.5 mg/mL (ultrasonic; warming)

Smiles

O=C(O)[C@H](CC1=CNC2=CC=CC=C12)NC([C@H](CCC(O)=O)N)=O

Molecular Formula

C16H19N3O5

Molecular Weight

333.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Bayes M, et al. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2005 Jul-Aug;27 (6) :411-61.|[2]Nagendra Kumar Kaushik, et al. Biomedical importance of indoles. Molecules. 2013 Jun 6;18 (6) :6620-62.|[3]Noy A, et al. Angiogenesis inhibitor IM862 is ineffective against AIDS-Kaposi's sarcoma in a phase III trial, but demonstrates sustained, potent effect of highly active antiretroviral therapy: from the AIDS Malignancy Consortium and IM862 Study Team. J Clin Oncol. 2005 Feb 10;23 (5) :990-8.|[4]Smith DL, et al. Natural killer cell cytolytic activity is necessary for in vivo antitumor activity of the dipeptide L-glutamyl-L-tryptophan. Int J Cancer. 2003 Sep 10;106 (4) :528-533.