ZM 306416

ZM-306416 (CB 676475) is a potent inhibitor of VEGFR with IC50s of 0.1 and 2 μM for KDR and Flt, respectively. ZM-306416 is also a EGFR inhibitor with an IC50 of <10 nM.

Product Specifications

CAS Number

[690206-97-4]

Product Name Alternative

CB 676475

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

VEGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/zm-306416.html

Purity

99.80

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

COC1=CC2=NC=NC(NC3=C(F)C=C(Cl)C=C3)=C2C=C1OC

Molecular Formula

C16H13ClFN3O2

Molecular Weight

333.75

Precautions

H302, H315, H319, H335

References & Citations

[1]Han SY, Park SS, Lee WG, Synthesis of a novel biotin-tagged photoaffinity probe for VEGF receptor tyrosine kinases. Bioorg Med Chem Lett. 2006 Jan 1;16 (1) :129-33.|[2]Antczak C, Mahida JP, Bhinder B, A high-content biosensor-based screen identifies cell-permeable activators and inhibitors of EGFR function: implications in drug discovery. J Biomol Screen. 2012 Aug;17 (7) :885-99.