Celastrol (Standard)

Celastrol (Standard) is the analytical standard of Celastrol. This product is intended for research and analytical applications. Celastrol (Tripterine; Tripterin) is a proteasome inhibitor which potently and preferentially inhibits the chymotrypsin-like activity of a purified 20S proteasome with IC50 of 2.5 μM.

Product Specifications

CAS Number

[34157-83-0]

Product Name Alternative

Tripterine (Standard) ; Tripterin (Standard)

UNSPSC

12352211

Hazard Statement

H301

Target

Apoptosis; Autophagy; Endogenous Metabolite; Mitophagy; Proteasome; Reference Standards

Type

Reference Standards

Related Pathways

Apoptosis; Autophagy; Metabolic Enzyme/Protease; Others

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/celastrol-standard.html

Purity

99.91

Smiles

OC1=C(C2=CC=C3[C@](C)([C@]4(CC[C@]3(C2=CC1=O)C)C)CC[C@@]5(C)CC[C@@](C(O)=O)(C[C@]54[H])C)C

Molecular Formula

C29H38O4

Molecular Weight

450.61

Precautions

H301

References & Citations

[1]Yang H, et al. Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine, " is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice. Cancer Res. 2006 May 1;66 (9) :4758-65|[2]Guan Y, et al. Celastrol attenuates oxidative stress in the skeletal muscle of diabetic rats by regulating the AMPK-PGC1α-SIRT3 signaling pathway. Int J Mol Med. 2016 May;37 (5) :1229-38.