PDMP (hydrochloride)

PDMP hydrochloride is a glucosylceramide synthase (GCS) inhibitor. PDMP hydrochloride induces apoptosis in K562/A02 cells. PDMP hydrochloride can be used in cancer (such as leukemia) research[1][2].

Product Specifications

CAS Number

[73257-80-4]

Product Name Alternative

4'-Fluoro-5'-O-sulfamoyladenosine; NSC 521007

UNSPSC

12352211

Hazard Statement

H319, H335

Target

Apoptosis; Glucosylceramide Synthase (GCS)

Type

Reference compound

Related Pathways

Apoptosis; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pdmp-hydrochloride.html

Purity

99.9

Solubility

DMSO : 30 mg/mL (ultrasonic; warming)

Smiles

CCCCCCCCCC(NC(CN1CCOCC1)C(C2=CC=CC=C2)O)=O.[x].Cl

Molecular Formula

C23H38lN2O3.xHCl

Precautions

H319, H335

References & Citations

[1]Casson L, et al. Inhibition of ceramide metabolism sensitizes human leukemia cells to inhibition of BCL2-like proteins. PLoS One. 2013;8 (1) :e54525.|[2]Yin L, et al. Effect of PDMP, a glucosylceramide synthase inhibitor, on reversion of daunorubicin resistance in human leukemia cell line K562/A02. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010 Feb;18 (1) :79-84.