PDMP (hydrochloride)
Product Specifications
Product Name Alternative
4'-Fluoro-5'-O-sulfamoyladenosine; NSC 521007
UNSPSC Description
PDMP hydrochloride is a glucosylceramide synthase (GCS) inhibitor. PDMP hydrochloride induces apoptosis in K562/A02 cells. PDMP hydrochloride can be used in cancer (such as leukemia) research[1][2].
Target Antigen
Apoptosis; Glucosylceramide Synthase (GCS)
Type
Reference compound
Related Pathways
Apoptosis;Neuronal Signaling
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pdmp-hydrochloride.html
Purity
99.0
Solubility
DMSO : 30 mg/mL (ultrasonic;warming)
Smiles
CCCCCCCCCC(NC(CN1CCOCC1)C(C2=CC=CC=C2)O)=O.[x].Cl
References & Citations
[1]Casson L, et al. Inhibition of ceramide metabolism sensitizes human leukemia cells to inhibition of BCL2-like proteins. PLoS One. 2013;8(1):e54525.|[2]Yin L, et al. Effect of PDMP, a glucosylceramide synthase inhibitor, on reversion of daunorubicin resistance in human leukemia cell line K562/A02. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010 Feb;18(1):79-84.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-116392D/PDMP-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-116392D/PDMP-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
73257-80-4
Available Sizes
Curated Selection
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