XSJ-10
Product Specifications
UNSPSC Description
XSJ-10 is a HDAC inhibitor containing a RAS/RAF protein interfering unit, with IC50s of 0.05 and 0.04 μM in PANC-1 cells and HT-29 cells. XSJ-10 can effectively induce the apoptosis of cancer cells and suppress the tumor by strongly inhibiting the RAS-RAF-MEK-ERK signaling pathway and the acetylation level of HDAC3[1].
Target Antigen
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/xsj-10.html
Solubility
10 mM in DMSO
Smiles
COC1=CC(OC)=C(C(OC)=C1)/C=C/S(CC2=CC=C(C(NCC(NO)=O)=C2)OC)(=O)=O
Molecular Weight
466.50
References & Citations
[1]Wang Y, et al. Multitargeting HDAC Inhibitors Containing a RAS/RAF Protein Interfering Unit. J Med Chem. 2024 Feb 8;67(3):2066-2082.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-157740/XSJ-10-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-157740/
Clinical Information
No Development Reported
Curated Selection
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