Ganodermanontriol

Ganodermanontriol, a sterol isolated from Ganoderma lucidum, induces anti-inflammatory activity in tert-butyl hydroperoxide (t-BHP) -damaged hepatic cells through the expression of HO-1. Ganodermanontriol exhibits hepatoprotective activity[1][2].

Product Specifications

CAS Number

[106518-63-2]

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Epigenetic Reader Domain; p38 MAPK

Type

Natural Products

Related Pathways

Epigenetics; MAPK/ERK Pathway

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ganodermanontriol.html

Purity

97.42

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1(C)C(CC[C@]2(C)C3=CC[C@]4(C)[C@@H]([C@H](C)CC[C@H](O)[C@](C)(O)CO)CC[C@](C)4C3=CC[C@@]12[H])=O

Molecular Formula

C30H48O4

Molecular Weight

472.70

Precautions

H315, H319, H335

References & Citations

[1]Kennedy EM, et al. Semisynthesis and biological evaluation of ganodermanontriol and its stereoisomeric triols. J Nat Prod. 2011 Nov 28;74 (11) :2332-7.|[2]Ha do T, et al. In vitro and in vivo hepatoprotective effect of ganodermanontriol against t-BHP-induced oxidative stress. Ethnopharmacol. 2013 Dec 12;150 (3) :875-85.|[3]Jedinak A, Thyagarajan-Sahu A, Jiang J, Sliva D. Ganodermanontriol, a lanostanoid triterpene from Ganoderma lucidum, suppresses growth of colon cancer cells through ß-catenin signaling. Int J Oncol. 2011;38 (3) :761-767. |[4]Park CH, et al. The Anti-Melanogenic Effects of Ganodermanontriol from the Medicinal Mushroom Ganoderma lucidum through the Regulation of the CREB and MAPK Signaling Pathways in B16F10 Cells. Molecules. 2024 Aug 22;29 (16) :3976.