MS41

MS41 is a selective eleven-nineteen leukemia (ENL) PROTAC degrader, with DC50s of 3.50 nM (MV4;11), 2.84 nM (SEMK2), 3.03 nM (Jurkat), and 26.58 nM (KASUMI1), respectively. MS41 effectively inhibits the growth of ENL-dependent leukemia cells, induces G1 cell cycle arrest and increases apoptosis. MS41 reduces the chromatin occupancy of ENL-associated transcription elongation machinery, and suppresses oncogenic gene expression and leukemia progression. Red: ENL ligand (HY-169094) . Black: linker (HY-W105744) . Blue: VHL ligand (HY-112078) [1].

Product Specifications

CAS Number

[2768610-97-3]

UNSPSC

12352005

Target

Apoptosis; Epigenetic Reader Domain; PROTACs

Type

Reference compound

Related Pathways

Apoptosis; Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ms41.html

Purity

98.97

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=C(SC=N1)C2=CC=C(C=C2)[C@@H](NC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(CCCCCCCCCNC(C4=CC=C5CC[C@H](C5=C4)NC(C6=NOC(C7=CC(O)=C(C=C7)C(N(C)C)=O)=C6)=O)=O)=O)=O)O)=O)C

Molecular Formula

C56H70N8O9S

Molecular Weight

1031.27

References & Citations

[1]Xue Z, et al. A potent and selective ENL degrader suppresses oncogenic gene expression and leukemia progression. Sci Adv. 2024 Aug 30;10 (35) :eado1432.