CXCR2-IN-1
CXCR2-IN-1 is a central nervous system penetrant CXCR2 antagonist with a pIC50 of 9.3.
Product Specifications
CAS Number
[1873376-49-8]
UNSPSC
12352005
Target
CXCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Endocrinology
Assay Protocol
https://www.medchemexpress.com/CXCR2-IN-1.html
Purity
99.54
Solubility
DMSO : 5.4 mg/mL (ultrasonic; warming)
Smiles
ClC1=CC=C(NC(NC2=CC=CC(F)=C2Cl)=O)C(O)=C1S(=O)(C3CCN(C)CC3)=O
Molecular Formula
C19H20Cl2FN3O4S
Molecular Weight
476.35
References & Citations
[1]Xu H, et al. Discovery of CNS Penetrant CXCR2 Antagonists for the Potential Treatment of CNS Demyelinating Disorders. ACS Med Chem Lett. 2016 Feb 8;7 (4) :397-402.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CXCR2
Available Sizes
Curated Selection
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