Paxalisib

Paxalisib (GDC-0084) is a brain penetrant inhibitor of PI3K and mTOR, with Kis of 2 nM, 46 nM, 3 nM, 10 nM and 70 nM for PI3Kα PI3Kβ, PI3Kδ, PI3Kγ and mTOR, respectively[1].

Product Specifications

CAS Number

[1382979-44-3]

Product Name Alternative

GDC-0084

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MTOR; PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/GDC-0084.html

Purity

99.51

Solubility

DMSO : 7.69 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

NC1=NC=C(C2=NC(N3CCOCC3)=C4N=C(C(C)(C)OCC5)N5C4=N2)C=N1

Molecular Formula

C18H22N8O2

Molecular Weight

382.42

Precautions

H302, H315, H319, H335

References & Citations

[1]Heffron TP, et al. Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR. ACS Med Chem Lett. 2016 Feb 16;7 (4) :351-6.