EN450
EN450 is a cysteine-reactive covalent molecular glue degrader targeting NF-κB. EN450 interacts with allosteric C111 in the E2 ubiquitin ligase UBE2D. EN450 induces the ternary complex formation between UBE2D and NFKB1. EN450 exerts its anti-proliferative effects through a Cullin E3 ligase and proteasome-dependent mechanism[1].
Product Specifications
CAS Number
[793719-01-4]
UNSPSC
12352005
Hazard Statement
H301, H311, H331, H341
Target
E1/E2/E3 Enzyme; Molecular Glues; NF-κB
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; NF-κB; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/en450.html
Concentration
10mM
Purity
98.59
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC(S(=O)(N(C)C)=O)=CC=C1Cl)C=C
Molecular Formula
C11H13ClN2O3S
Molecular Weight
288.76
Precautions
H301, H311, H331, H341
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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