Acetohydroxamic acid

Acetohydroxamic acid is the inhibitor for bacterial and plant urease that can be used for chronic urinary tract infections. Acetohydroxamic acid selectively inhibits arachidonic acid 5-lipoxygenase that is useful in the research of asthma. Acetohydroxamic acid inhibits the formation of advanced glycation end products, and reduces oxidative stress and inflammatory responses. Acetohydroxamic acid exhibits antiviral activity against HIV[1][2][3].

Product Specifications

CAS Number

[546-88-3]

Product Name Alternative

N-Hydroxyacetamide

UNSPSC

12352211

Hazard Statement

H360

Target

Bacterial; HIV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Acetohydroxamic-acid.html

Concentration

10mM

Purity

98.66

Solubility

DMSO : 233.33 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

CC(NO)=O

Molecular Formula

C2H5NO2

Molecular Weight

75.07

Precautions

H360

References & Citations

[1]Sharma M, et al. Biotransformation of Acetamide to Acetohydroxamic Acid at Bench Scale Using Acyl Transferase Activity of Amidase of Geobacillus pallidus BTP-5x MTCC 9225. Indian J Microbiol. 2012 Mar;52 (1) :76-82.|[2]Umamaheshwari RB, et al., Receptor-mediated targeting of lipobeads bearing acetohydroxamic acid for eradication of Helicobacter pylori. J Control Release. 2004 Sep 14;99 (1) :27-40.|[3]Liu YH, et al., Antiglycation, radical scavenging, and semicarbazide-sensitive amine oxidase inhibitory activities of acetohydroxamic acid in vitro. Drug Des Devel Ther. 2017 Jul 13;11:2139-2147.