Degrasyn

Degrasyn (WP1130) is a cell-permeable deubiquitinase (DUB) inhibitor, directly inhibiting DUB activity of USP9x, USP5, USP14, and UCH37. Degrasyn has been shown to downregulate the antiapoptotic proteins Bcr-Abl and JAK2.

Product Specifications

CAS Number

[856243-80-6]

Product Name Alternative

WP1130

UNSPSC

12352005

Hazard Statement

H301, H311, H331

Target

Apoptosis; Autophagy; Bcr-Abl; Deubiquitinase

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/WP1130.html

Purity

99.70

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

BrC1=CC=CC(/C=C(C(N[C@H](C2=CC=CC=C2)CCC)=O)\C#N)=N1

Molecular Formula

C19H18BrN3O

Molecular Weight

384.27

Precautions

H301, H311, H331

References & Citations

[1]Bartholomeusz GA, et al. Activation of a novel Bcr/Abl destruction pathway by WP1130 induces apoptosis of chronic myelogenous leukemia cells. Blood. 2007 Apr 15;109 (8) :3470-8.