DPhPC

DPhPC is a derivative of phosphatidylcholine (PC) used to synthesize bilayer vesicle phospholipids. DPhPC bilayer membranes do not leak ions in the absence of pores or ion channels, so they are often used to study the activity of ion channels and the regulation of membrane potential. Nanoliposomes (NTG) prepared based on DPhPC can improve the bioavailability of nitric oxide (NO) and have anti-inflammatory effects[1][2][3].

Product Specifications

CAS Number

[207131-40-6]

UNSPSC

12352200

Hazard Statement

H315, H317, H319, H335, H360

Target

Biochemical Assay Reagents; Liposome

Type

Biochemical Assay Reagents

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/dphpc.html

Purity

99.77

Solubility

DMSO : 3.57 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC(C)CCCC(C)CCCC(C)CCCC(C)CC(O[C@@H](COP(OCC[N+](C)(C)C)([O-])=O)COC(CC(C)CCCC(C)CCCC(C)CCCC(C)C)=O)=O

Molecular Formula

C48H96NO8P

Molecular Weight

846.25

Precautions

H315, H317, H319, H335, H360

References & Citations

[1]Schmidt D, et, al. A gating model for the archeal voltage-dependent K (+) channel KvAP in DPhPC and POPE:POPG decane lipid bilayers. J Mol Biol. 2009 Jul 31;390 (5) :902-12. |[2]Andersson M, et, al. Vesicle and bilayer formation of diphytanoylphosphatidylcholine (DPhPC) and diphytanoylphosphatidylethanolamine (DPhPE) mixtures and their bilayers' electrical stability. Colloids Surf B Biointerfaces. 2011 Feb 1;82 (2) :550-61.|[3]Ardekani S, et al. Nanoliposomal nitroglycerin exerts potent anti-inflammatory effects[J]. Scientific reports, 2015, 5 (1) : 16258.