Ditolylguanidine

Ditolylguanidine (1,3-Di-o-tolylguanidine) is an agonist of sigma receptor (σ1/σ2 receptor) with Ki values of 69 and 21 nM for σ1 and σ2 receptors, respectively. Ditolylguanidine effectively inhibits the growth of small cell lung cancer cells. Ditolylguanidine can be used for the research of lung cancer[1][2][3][4].

Product Specifications

CAS Number

[97-39-2]

Product Name Alternative

1,3-Di-o-tolylguanidine; DTG

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Sigma Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ditolylguanidine.html

Purity

99.66

Solubility

DMSO : 150 mg/mL (ultrasonic)

Smiles

CC1=C(NC(NC2=CC=CC=C2C)=N)C=CC=C1

Molecular Formula

C15H17N3

Molecular Weight

239.32

Precautions

H302, H315, H319, H335

References & Citations

[1]Shimizu I, et al. Effects of (+) -pentazocine and 1,3-di-o-tolylguanidine (DTG), sigma (sigma) ligands, on micturition in anaesthetized rats. Br J Pharmacol. 2000 Oct;131 (3) :610-6.|[2]John CS, et al. Sigma receptors are expressed in human non-small cell lung carcinoma. Life Sci. 1995;56 (26) :2385-92.|[3]Moody TW, et al. Sigma ligands inhibit the growth of small cell lung cancer cells. Life Sci. 2000 Apr 7;66 (20) :1979-86.|[4]Moison D, et al. Intrastriatal administration of sigma ligands inhibits basal dopamine release in vivo. Neuropharmacology. 2003 Dec;45 (7) :945-53.