DEL-22379
DEL-22379 is an ERK dimerization Inhibitor. DEL-22379 readily binds to ERK2 with a Kd estimated in the low micromolar range, though binding is detectable even at low nanomolar concentrations. ERK2 dimerization is progressively inhibited with an IC50 of ~0.5 μM.
Product Specifications
CAS Number
[181223-80-3]
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Apoptosis; ERK
Type
Reference compound
Related Pathways
Apoptosis; MAPK/ERK Pathway; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/DEL-22379.html
Purity
99.69
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(CCN1CCCCC1)NC2=CC=C(NC(/C3=C\C4=CNC5=C4C=C(OC)C=C5)=O)C3=C2
Molecular Formula
C26H28N4O3
Molecular Weight
444.53
Precautions
H315, H319
References & Citations
[1]Herrero A, et al. Small Molecule Inhibition of ERK Dimerization Prevents Tumorigenesis by RAS-ERK Pathway Oncogenes. Cancer Cell. 2015 Aug 10;28 (2) :170-82.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERK2
Available Sizes
Curated Selection
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